Treatment of bacterial infections of the female urinary tract by immunization of the patients.

Abstract

In an open comparative study 400 patients with urinary tract infections were randomly allocated to two treatment groups. In 202 patients an immune stimulation against uropathogenic bacteria was produced with a new preparation, SolcoUrovac, and only in exceptional cases with pronounced symptomatology was antibiotic therapy given, while in the control group (n = 198) all patients were treated with nitrofurantoin or with another appropriate antibiotic, according to the antibiogram. In the subsequent 12-month observation period 28 infections occurred in 23 patients of the immune-stimulated group and 84 in 47 patients of the control group. This difference is statistically significant (p less than or equal to 0.001). The preventive effect of the SolcoUrovac therapy was particularly impressive in patients with recurrent urinary tract infections. Thirty-two patients from each group with similar case histories, as matched pairs, were evaluated separately. The relapse rate in the 12-month observation period amounted to 2 re-infections in the group treated with immunotherapy and to 29 in the control group. All side-effects were recorded. No adverse effects were observed in pregnant women or in their offspring.

• Authors: E M Grischke, H Rüttgers
• Journal: Urologia internationalis (Urol Int) Vol. 42 Issue 5 Pg. 338-41 ( 1987) ISSN: 0042-1138 [Print] Switzerland
• PMID: 3324441 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Bacterial Vaccines
• Nitrofurantoin

Topics

• Bacterial Infections (therapy)
• Bacterial Vaccines (therapeutic use)
• Bacteriuria (therapy)
• Clinical Trials as Topic
• Cystitis (therapy)
• Female
• Humans
• Nitrofurantoin (therapeutic use)
• Pyelonephritis (therapy)
• Random Allocation
• Urinary Tract Infections (therapy)