Serum Neuropeptide Y Level is Associated with Post-Ischemic Stroke Epilepsy.

Abstract

BACKGROUND AND PURPOSE:

Post-ischemic stroke epilepsy (PISE) is one of the common complications of stroke.

MATERIALS AND METHODS:

Methods To determine the risk factors of PISE, in this study, 78 patients with PISE and 86 patients without PISE were recruited. Clinical data and serum neuropeptide Y (NPY) levels were collected and the relative factors including clinical data and serum were analyzed.

RESULTS:

Logistic regression showed that low serum NPY was significantly associated with PISE. Every 5 ng/ml increment of serum NPY was associated with 62% risk decrease in patients with PISE. The area under curve of serum NPY was 0.910 with a sensitivity of 84.62% and a specificity of 86.05%. The cut-off value of serum NPY was 90 ng/ml. According to cut-off value of serum NPY, the percentage of patients with PISE decreased from 84.6% in low serum NPY group to 14.0% in high serum NPY group. Furthermore, patients were divided into different tertiles according to serum NPY. The percentage of patients with PISE reduced from 90.0% in the lowest tertile (NPY < 85 ng/ml) to 3.5% in the highest tertile (NPY ≥ 105 ng/ml). Compared with patients with normal video-electroencephalogram (VEEG), serum NPY levels significantly decreased in patients with abnormal VEEG; however, serum NPY levels were not associaated with epileptic seizure subtypes.

CONCLUSIONS:

Serum NPY was an independent risk factor for PISE. Targeting serum NPY may be used to the prevention and treatment of PISE.

• Authors: Nuan Wang, Dongxing Wang, Hao Zhou, Cuifu Xu, Xiaowei Hu, Zhiyuan Qian, Xingshun Xu
• Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association (J Stroke Cerebrovasc Dis) Vol. 30 Issue 2 Pg. 105475 (Feb 2021) ISSN: 1532-8511 [Electronic] United States
• PMID: 33242785 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Neuropeptide Y

Topics

• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Case-Control Studies
• Electroencephalography
• Epilepsy (diagnosis, etiology)
• Female
• Humans
• Male
• Middle Aged
• Neuropeptide Y (blood)
• Predictive Value of Tests
• Risk Assessment
• Risk Factors
• Stroke (blood, complications, diagnosis)