The emerging role of miR-128 in musculoskeletal diseases.

Abstract

MicroRNA-128 (miR-128) is associated with cell proliferation, differentiation, migration, apoptosis, and survival. Genetic analysis studies have demonstrated that miR-128 participates in bone metabolism, which involves bone marrow-derived mesenchymal stem cells, osteoblasts, osteoclasts, and adipocytes. miR-128 also participates in regeneration of skeletal muscles by targeting myoblast-associated proteins. The deregulation of miR-128 could lead to a series of musculoskeletal diseases. In this review, we discuss recent findings of miR-128 in relation to bone metabolism and muscle regeneration to determine its potential therapeutic effects in musculoskeletal diseases, and to propose directions for future research in this significant field.

• Authors: Qi Shang, Gengyang Shen, Guifeng Chen, Zhida Zhang, Xiang Yu, Wenhua Zhao, Peng Zhang, Honglin Chen, Kai Tang, Fuyong Yu, Jingjing Tang, De Liang, Xiaobing Jiang, Hui Ren
• Journal: Journal of cellular physiology (J Cell Physiol) Vol. 236 Issue 6 Pg. 4231-4243 (06 2021) ISSN: 1097-4652 [Electronic] United States
• PMID: 33241566 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2020 Wiley Periodicals LLC.

Chemical References

• MIRN128 microRNA, human
• MicroRNAs

Topics

• Arthritis (genetics, metabolism, physiopathology)
• Bone Remodeling (genetics)
• Exosomes (genetics, metabolism)
• Gene Expression Regulation
• Humans
• Male
• MicroRNAs (genetics, metabolism)
• Muscle Development (genetics)
• Musculoskeletal Diseases (genetics, metabolism, physiopathology)
• Musculoskeletal System (metabolism, physiopathology)
• Osteogenesis (genetics)
• Osteoporosis (genetics, metabolism, physiopathology)