Abstract |
In 23 patients with idiopathic Parkinson's disease presenting with severe fluctuations in motor performance and 'on-off' phenomena after long-term treatment with levodopa, the standard form of Madopar was replaced by the controlled-release form Madopar HBS. The Meerwaldt's patient card has been used to evaluate the frequency and intensity of response swings. Only 2 patients, who suffered from clear-cut 'end-of-dose' deterioration, significantly benefited by this switch from standard Madopar to Madopar HBS. Eight patients had a minimal or not essential improvement of the parkinsonian symptomatology and/or of the response fluctuations. Thirteen patients returned to their previous standard Madopar treatment after deterioration of parkinsonian symptoms or increase of dyskinesia under the HBS treatment. The overall increase in dosage of levodopa with Madopar HBS was 54% in comparison with the initial standard Madopar dosage.
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Authors | E N Jansen, J D Meerwaldt, T Heersema, J van Manen, J D Speelman |
Journal | European neurology
(Eur Neurol)
Vol. 27 Suppl 1
Pg. 88-92
( 1987)
ISSN: 0014-3022 [Print] Switzerland |
PMID | 3322841
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Delayed-Action Preparations
- Drug Combinations
- Hydrazines
- benserazide, levodopa drug combination
- Levodopa
- Benserazide
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Topics |
- Aged
- Benserazide
(administration & dosage, pharmacokinetics, therapeutic use)
- Clinical Trials as Topic
- Delayed-Action Preparations
- Dose-Response Relationship, Drug
- Drug Combinations
(pharmacokinetics, therapeutic use)
- Female
- Humans
- Hydrazines
(therapeutic use)
- Levodopa
(administration & dosage, pharmacokinetics, therapeutic use)
- Male
- Middle Aged
- Movement Disorders
(drug therapy, etiology)
- Parkinson Disease
(complications, drug therapy, physiopathology)
- Time Factors
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