Tubulointerstitial nephritis by Tamm-Horsfall glycoprotein or egg white component.

Abstract

Experimental tubulointerstitial nephritis (TIN) was induced in Wistar rats and New Zealand white rabbits by direct intrarenal inoculation of Tamm-Horsfall glycoprotein (THG) or egg white component (egg white A). After five immunizations of THG or egg white A with complete Freund's adjuvant (CFA), direct intrarenal inoculation of THG or egg white A also induced more severe TIN in the inoculated kidney. By the 7th day, in 1 of the animals with immunizations and then intrarenal inoculation of THG, the inoculated kidney was swollen and appeared necrotic. By the 28th day, in 1 of those receiving immunizations and intrarenal inoculation of THG, the inoculated kidney became contracted. TIN was observed in three experimental models, namely (a) direct intrarenal inoculation of THG or egg white A; (b) five immunizations of THG and (c) immunizations and then intrarenal inoculations of THG or egg white A. The most severe TIN was observed in the latter model.

• Authors: T Nagai, T Nagai
• Journal: Nephron (Nephron) Vol. 47 Issue 2 Pg. 134-40 ( 1987) ISSN: 1660-8151 [Print] Switzerland
• PMID: 3320775 (Publication Type: Journal Article)

Chemical References

• Mucoproteins
• Uromodulin

Topics

• Animals
• Antibody Formation
• Egg White
• Fluorescent Antibody Technique
• Immunity, Cellular
• Immunization
• Immunization, Secondary
• Kidney (immunology, pathology)
• Mucoproteins
• Nephritis, Interstitial (chemically induced, immunology, pathology)
• Rabbits
• Rats
• Rats, Inbred Strains
• Uromodulin