Insulin receptor evaluation in congenital generalized lipodystrophy. Case report of an infant.

Abstract

Insulin specific receptors on red blood cells and cultured fibroblasts were investigated in a male infant affected of congenital generalized lipodystrophy (CGL). Total insulin binding capacity appeared mildly reduced, with apparently selective involvement of the high-affinity receptors on red blood cells but not on fibroblasts. Such alterations did not produce any impairment of glucose metabolism.

• Authors: M Aricò, A Ricordi, D Caselli, M Aschei, A Colombo, P Fratino
• Journal: Helvetica paediatrica acta (Helv Paediatr Acta) Vol. 42 Issue 2-3 Pg. 167-71 (Oct 1987) ISSN: 0018-022X [Print] Switzerland
• PMID: 3319972 (Publication Type: Case Reports, Journal Article)

Chemical References

• Blood Glucose
• Insulin
• Receptor, Insulin

Topics

• Blood Glucose (metabolism)
• Cells, Cultured
• Erythrocytes (metabolism)
• Fibroblasts (metabolism)
• Glucose Tolerance Test
• Humans
• Infant
• Insulin (blood)
• Lipodystrophy (congenital, metabolism, physiopathology)
• Male
• Receptor, Insulin (metabolism)