HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

A comparison of two doses of adriamycin in the primary chemotherapy of disseminated breast carcinoma.

Abstract
Forty-eight patients with advanced breast carcinoma who had not received prior chemotherapy (minimum follow up 21 months) were randomised to receive either adriamycin 70 mg m-2 i.v. 3-weekly for 8 cycles (Regimen A) or adriamycin 35 mg m-2 i.v. 3-weekly for 16 courses (Regimen B). Objective responses were seen in 14/24 (58%) patients with regimen A (4 complete) and 6/24 (25%) with regimen B (1 complete) (P less than 0.02). The median duration of response was 14 months with regimen A and 6.5 months with regimen B. The median duration of survival was 20 months and 8 months respectively (P less than 0.01). The toxicity was similar with each regimen. There was no evidence of deterioration in left ventricular ejection fraction nor congestive heart failure in any patient. It is concluded that when given at 3-weekly intervals adriamycin is a more effective treatment for advanced breast cancer at higher rather than lower dosage.
AuthorsJ Carmo-Pereira, F O Costa, E Henriques, F Godinho, M G Cantinho-Lopes, A Sales-Luis, R D Rubens
JournalBritish journal of cancer (Br J Cancer) Vol. 56 Issue 4 Pg. 471-3 (Oct 1987) ISSN: 0007-0920 [Print] ENGLAND
PMID3318902 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Doxorubicin
Topics
  • Adult
  • Aged
  • Breast Neoplasms (drug therapy)
  • Clinical Trials as Topic
  • Doxorubicin (administration & dosage, therapeutic use)
  • Drug Administration Schedule
  • Female
  • Humans
  • Middle Aged
  • Random Allocation
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: