Long-term antiplatelet therapy in medically managed non-ST-segment elevation acute coronary syndromes: The EPICOR Asia study.

Abstract

OBJECTIVES:

To describe long-term antithrombotic management patterns (AMPs) in medically managed Asian patients with non-ST-segment myocardial infarction (NSTEMI) or unstable angina (UA).

BACKGROUND:

Current guidelines support an early invasive strategy in NSTEMI and UA patients, but many are medically managed, and data are limited on long-term AMPs in Asia.

METHODS:

Data were analyzed from medically managed NSTEMI and UA patients included in the prospective, observational EPICOR Asia study (NCT01361386). Survivors to hospital discharge were enrolled (June 2011 to May 2012) from 8 countries/regions across Asia. Baseline characteristics and AMP use up to 2 years post-discharge were collected. Outcomes were major adverse cardiovascular events (MACE: myocardial infarction, ischemic stroke, and death) and bleeding.

RESULTS:

Among 2289 medically managed patients, dual antiplatelet therapy (DAPT) use at discharge was greater in NSTEMI than in UA patients (81.8% vs 65.3%), and was significantly associated with male sex, positive cardiac markers, and prior cardiovascular medications (p < 0.0001). By 2 years, 57.9% and 42.6% of NSTEMI and UA patients, respectively, were on DAPT. On multivariable Cox regression analysis, risk of MACE at 2 years was most significantly associated with older age (HR [95% CI] 1.85 [1.36, 2.50]), diagnosis of NSTEMI vs UA (1.96 [1.47, 2.61]), and chronic renal failure (2.14 [1.34, 3.41]), all p ≤ 0.001. Risk of bleeding was most significantly associated with region (East Asia vs Southeast/South Asia) and diabetes.

CONCLUSIONS:

Approximately half of all patients were on DAPT at 2 years. MACE were more frequent in NSTEMI than UA patients during follow-up.

• Authors: Juan Zhou, Chee Tang Chin, Xin Huang, Ning Guo, Yue Wu, Bo Yu, Shubin Qiao, Jiyan Chen, Yaling Han, Junbo Ge, Stuart J Pocock, Yong Huo, Zhaohong Wang, Zuyi Yuan
• Journal: International journal of cardiology (Int J Cardiol) Vol. 327 Pg. 19-24 (03 15 2021) ISSN: 1874-1754 [Electronic] Netherlands
• PMID: 33186669 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Chemical References

• Platelet Aggregation Inhibitors

Topics

• Acute Coronary Syndrome (diagnosis, drug therapy, epidemiology)
• Aftercare
• Aged
• Asia (epidemiology)
• Asia, Eastern
• Humans
• Male
• Patient Discharge
• Platelet Aggregation Inhibitors (adverse effects)
• Prospective Studies
• Treatment Outcome