Abstract | BACKGROUND: RECENT DEVELOPMENTS: Four randomised controlled trials have tested the efficacy of three new therapies ( eculizumab, satralizumab, and inebilizumab) for patients with neuromyelitis optica spectrum disorder that all showed a benefit in preventing future attacks. These therapies have different targets within the immune pathogenic process, and the four trials have similarities and differences that mean they might change the therapeutic landscape for people with neuromyelitis optica spectrum disorder in different ways. Efficacy, safety, tolerability, and practical considerations, including potential cost, differ for each drug and might affect the rate of use in real-world populations of patients with neuromyelitis optica spectrum disorder. WHERE NEXT?: Despite the rarity of neuromyelitis optica spectrum disorder, a relative abundance of preventive treatment options now exists. In the future, trials should focus on areas of unmet need, including aquaporin-4 seronegative disease, and on development of treatments for acute relapses and for recovery from autoimmune attacks in the CNS.
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Authors | Michael Levy, Kazuo Fujihara, Jacqueline Palace |
Journal | The Lancet. Neurology
(Lancet Neurol)
Vol. 20
Issue 1
Pg. 60-67
(01 2021)
ISSN: 1474-4465 [Electronic] England |
PMID | 33186537
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2020 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antibodies, Monoclonal, Humanized
- Immunologic Factors
- inebilizumab
- eculizumab
- satralizumab
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Topics |
- Antibodies, Monoclonal, Humanized
(administration & dosage, adverse effects, pharmacology)
- Humans
- Immunologic Factors
(administration & dosage, adverse effects, pharmacology)
- Neuromyelitis Optica
(drug therapy)
- Randomized Controlled Trials as Topic
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