ROS plays an important role in the formation of
atherosclerotic plaque, especially
hydrogen peroxide, which can stimulate macrophages to express pro-inflammatory
cytokines and
chemokines to enhance the inflammatory activity of macrophages. Therefore, the development of drugs with sensitive release of
hydrogen peroxide is safe and effective for the treatment of
atherosclerosis The side chain
hydroxyl groups of
pHEMA were grafted with oxalylsimvastatin (SIM), fluoropolyethylene glycol (fpeg) and macrophage target molecule ISO-1 to prepare
hydrogen peroxide sensitive fluorescent
drug loaded nanomicelles (phema-simfpeg-iso-1). By using
hydrogen peroxide sensitive and controlled-release drug, it can target macrophage, at the same time, improve the characteristics of traditional
polyethylene glycol only as hydrophilic chain, and synthesize
polyethylene glycol with fluorescence function, so that the
polymer can have probe ability without modifying fluorescence substance, which is suitable for the diagnosis and treatment of
atherosclerosis. The results show that the water-soluble nanoparticles show good biocompatibility and
peroxide Hydrogen sensitivity and fluorescence ability provide new materials for the development of a nano system for the diagnosis and treatment of
atherosclerosis.