Preoperative AminoIndex Cancer Screening (AICS) abnormalities predict postoperative recurrence in patients undergoing curative resection for non-small cell lung cancer.

Abstract

BACKGROUND:

AminoIndex™ Cancer Screening (AICS (lung)) was developed as a screening test for lung cancer using a multivariate analysis of plasma-free amino acid (PFAA) profiles. According to the developed index composed of PFAA, the probability of lung cancer was categorized into AICS (lung) ranks A, B, and C in order of increasing risk. The aim of the present study was to investigate the relationship between the preoperative AICS (lung) rank and surgical outcomes in patients who underwent curative resection for non-small cell lung cancer (NSCLC).

METHODS:

Preoperative blood samples were collected from 297 patients who underwent curative resection for NSCLC between 2006 and 2015. PFAA concentrations were measured. The relationship between the preoperative AICS (lung) rank and clinicopathological factors was examined. The effects of the preoperative AICS (lung) rank on postoperative outcomes were also analyzed.

RESULTS:

The AICS (lung) rank was A in 93 patients (31.3%), B in 82 (27.6%), and C in 122 (41.1%). The AICS (lung) rank did not correlate with any clinicopathological factors, except for age. Based on follow-up data (median follow-up period of 6 years), postoperative recurrence was observed in 22 rank A patients (23.7%), 15 rank B (18.3%) and 49 rank C (40.2%). In the univariate analysis, preoperative AICS (lung) rank C was a worse factor of recurrence-free survival (p = 0.0002). The multivariate analysis identified preoperative AICS (lung) rank C (HR: 2.17, p = 0.0005) as a significant predictor of postoperative recurrence, particularly in patients with early-stage disease or adenocarcinoma.

CONCLUSION:

Preoperative AICS (lung) rank C is a high-risk predictor of postoperative recurrence in patients undergoing curative resection for NSCLC.

• Authors: Masahiko Higashiyama, Ryohei Miyazaki, Hiroshi Yamamoto, Takashi Anayama, Shinya Kikuchi, Kentaro Hirohashi, Jiro Okami, Tomohiro Maniwa, Toru Kimura, Kazumasa Orihashi, Fumio Imamura
• Journal: BMC cancer (BMC Cancer) Vol. 20 Issue 1 Pg. 1100 (Nov 12 2020) ISSN: 1471-2407 [Electronic] England
• PMID: 33183251 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Biomarkers, Tumor

Topics

• Adenocarcinoma of Lung (pathology, surgery)
• Adult
• Aged
• Aged, 80 and over
• Amino Acids (blood)
• Biomarkers, Tumor (blood)
• Carcinoma, Non-Small-Cell Lung (pathology, surgery)
• Carcinoma, Squamous Cell (pathology, surgery)
• Early Detection of Cancer (methods)
• Female
• Follow-Up Studies
• Humans
• Lung Neoplasms (pathology, surgery)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (blood, diagnosis, epidemiology)
• Pneumonectomy (mortality)
• Postoperative Complications (blood, diagnosis, epidemiology)
• Preoperative Care
• Prognosis
• Retrospective Studies
• Survival Rate