[Effect of trypsin and kallikrein (andecalin) on the activity of proteolytic enzymes and their inhibitors in acute experimental pancreatitis].

Abstract

Intramuscular administration of trypsin and kallikrein (andecaline) into rats contributed to more favourable development of acute traumatic pancreatitis. Trypsin and andecaline prevented the activation of proteinases in blood serum and pancreas and promoted an increase in content of trypsin inhibitor in blood serum. The proteinases efficiency appears to depend on elevation of general resistance of the organism to the trauma.

• Authors: Iu V Kolenda, V E Vansovich, S V Vovchuk, A P Levitskiĭ
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1987 Sep-Oct Vol. 33 Issue 5 Pg. 122-4 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Vliianie tripsina i kallikreina (andekalina) na aktivnost' proteoliticheskikh fermentov i ikh ingibitorov pri ostrom éksperimental'nom pankreatite.
• PMID: 3318106 (Publication Type: English Abstract, Journal Article)

Chemical References

• Protease Inhibitors
• Peptide Hydrolases
• Kallikreins
• Trypsin

Topics

• Acute Disease
• Animals
• Enzyme Activation
• Hydrolysis
• Kallikreins (therapeutic use)
• Pancreatitis (drug therapy, enzymology)
• Peptide Hydrolases (blood)
• Protease Inhibitors (blood)
• Rats
• Rats, Inbred Strains
• Trypsin (therapeutic use)