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Alpha-tocopherol: effect on plasma lipoproteins in hypercholesterolemic patients.

Abstract
This study was designed to examine the hypothesis that dl-alpha-tocopheryl acetate (vitamin E) increases the level of high-density lipoprotein cholesterol (HDLC) with a concomitant decrease of the ratio of total cholesterol/HDLC and a resultant amelioration of the coronary risk profile. Vitamin E (500 IU/day) or placebo were administered under double-blind randomized allocation to 69 hypercholesterolemic patients for 3 months. Sixty patients completed the study (30 in the active treatment group and 30 in the placebo group). Vitamin E raised the mean level of HDLC from 1.39 +/- 0.38 (SD) to 1.58 +/- 0.41 mmol, a 13.6% increase. This increase significantly (P less than 0.05) exceeded a parallel smaller increase of only 0.05 mmol (3.8%) in the placebo group. As total cholesterol (TC) declined by similar proportions in the vitamin E (7.8%) and placebo (9.4%) groups, a concomitant reduction of 23% in the TC/HDLC ratio was achieved in the vitamin E group, significantly exceeding a 9.1% reduction under placebo. Significant beneficial effects were noted on apolipoprotein (Apo) A (which rose) and Apo B (which declined). An increase of Apo A/Apo B ratio by 17.9% was observed only in the vitamin E group. These results suggest that the oral administration of vitamin E (500 IU/day) is beneficial in hyperlipoproteinemia and offers a potential tool for treating the increased coronary heart disease risk.
AuthorsM J Cloarec, G M Perdriset, F A Lamberdiere, J F Colas-Belcour, J P Sauzieres, H N Neufeld, U Goldbourt
JournalIsrael journal of medical sciences (Isr J Med Sci) Vol. 23 Issue 8 Pg. 869-72 (Aug 1987) ISSN: 0021-2180 [Print] Israel
PMID3316118 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Apolipoproteins A
  • Apolipoproteins B
  • Cholesterol, HDL
  • Vitamin E
Topics
  • Apolipoproteins A (blood)
  • Apolipoproteins B (blood)
  • Cholesterol, HDL (blood)
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Hypercholesterolemia (blood, drug therapy)
  • Male
  • Random Allocation
  • Vitamin E (therapeutic use)

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