Research on the midterm efficacy and prognosis of patients with diffuse large B-cell lymphoma by different evaluation methods in interim PET/CT.

Abstract

PURPOSE:

To investigate the midterm efficacy and prognostic evaluation of patients with diffuse large B-cell lymphoma (DLBCL) by three image analysis methods: International Harmonization Project (IHP), Deauville 5-Point Scale (5-PS) and Δ SUVmax criteria in 18F-FDG PET/CT.

METHODS:

This was a retrospective analysis of 141 patients with DLBCL. All patients were given 3-4 cycles of chemotherapy and 18F-FDG PET/CT. According to three criteria, the patients were divided into negative and positive groups, respectively. Statistical methods were used to assess the midterm efficacy and prognosis factors.

RESULTS:

During the midterm follow-up, a total of 109 people achieved CR. Three methods showed statistically significant differences in OS and PFS for the interim PET/CT, and Δ SUVmax criterion was an independent risk factor for the prognosis of DLBCL patients.

CONCLUSION:

In our research, IHP, 5-PS and Δ SUVmax criteria all had a significant predictive value, while Δ SUVmax criterion had more advantages in evaluating the midterm efficacy and predicting prognosis for patients with DLBCL in interim PET/CT. But it should be noticed that Δ SUVmax criterion needs more strict guidelines in multicenter trials. The optimal cutoff value of Δ SUVmax% we recommended was 81.54%, which helped to judge the midterm efficacy.

• Authors: Xingying Li, Xinli Xie, Lei Zhang, Xin Li, Ling Li, Xinhua Wang, Xiaorui Fu, Zhenchang Sun, Xudong Zhang, Zhaoming Li, Jingjing Wu, Hui Yu, Yu Chang, Jiaqin Yan, Zhiyuan Zhou, Feifei Nan, Xiaolong Wu, Li Tian, Mingzhi Zhang
• Journal: European journal of radiology (Eur J Radiol) Vol. 133 Pg. 109301 (Dec 2020) ISSN: 1872-7727 [Electronic] Ireland
• PMID: 33157372 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier B.V. All rights reserved.

Chemical References

• Fluorodeoxyglucose F18

Topics

• Fluorodeoxyglucose F18
• Humans
• Lymphoma, Large B-Cell, Diffuse (diagnostic imaging, drug therapy)
• Positron Emission Tomography Computed Tomography
• Positron-Emission Tomography
• Prognosis
• Retrospective Studies