Abstract |
Twenty-eight patients with osteoarthritis participated in a prospective, double-blind, cross-over study to compare the safety and efficacy of a new combination analgesic containing ibuprofen 200 mg, paracetamol 250 mg and codeine phosphate 10 mg per tablet ( Myprodol; Rio Ethicals) with a standard treatment regimen ( ibuprofen 200 mg per tablet). The combination tablet was found to provide significantly better pain relief than ibuprofen alone (P less than 0.05). Analysis of the results of haematological, hepatic and renal function tests showed no statistically significant differences between treatments. No serious side-effects or clinically important changes were encountered with either drug.
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Authors | G J Vlok, J P van Vuren |
Journal | South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde
(S Afr Med J)
Vol. Suppl
Pg. 1, 4-6
(Oct 17 1987)
ISSN: 0256-9574 [Print] South Africa |
PMID | 3313757
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Drug Combinations
- Acetaminophen
- Codeine
- Ibuprofen
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Topics |
- Acetaminophen
(administration & dosage, adverse effects)
- Adult
- Aged
- Aged, 80 and over
- Clinical Trials as Topic
- Codeine
(administration & dosage, adverse effects)
- Double-Blind Method
- Drug Combinations
- Female
- Humans
- Ibuprofen
(administration & dosage, adverse effects)
- Male
- Middle Aged
- Osteoarthritis
(drug therapy)
- Random Allocation
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