Comparison of L-baclofen and racemic baclofen in trigeminal neuralgia.

Abstract

L-Baclofen was compared with racemic baclofen (Lioresal) in a double-blind crossover trial in 15 patients with typical trigeminal neuralgia. L-Baclofen was more effective than five times as much racemic baclofen in nine patients. Six of these nine patients have continued pain-free on L-baclofen for 4 to 17 months (mean, 10 months). L-Baclofen was much better tolerated than racemic baclofen. Our results suggest that L-baclofen represents a significant improvement over racemic baclofen in the treatment of trigeminal neuralgia, and support our laboratory observations indicating that D-baclofen antagonizes the action of L-baclofen.

• Authors: G H Fromm, C F Terrence
• Journal: Neurology (Neurology) Vol. 37 Issue 11 Pg. 1725-8 (Nov 1987) ISSN: 0028-3878 [Print] United States
• PMID: 3313099 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Baclofen

Topics

• Adult
• Aged
• Baclofen (adverse effects, therapeutic use)
• Clinical Trials as Topic
• Double-Blind Method
• Humans
• Isomerism
• Middle Aged
• Trigeminal Neuralgia (drug therapy, physiopathology)