Abstract |
Effects of a novel synthetic compound, Y-19995, on the host defence in immunocompromised mice were investigated in terms of the restoration of leukocytopenia and the protection against several microbial infections. Oral or intravenous administration of Y-19995 into mice after X-irradiation, treatment with cyclophosphamide or mitomycin C prevented the leukocytopenia to some extent and promoted the restoration in cell numbers of both the peripheral blood leukocytes and bone marrow. Intravenous administration of Y-19995 increased significantly the survival rates of X-ray irradiated mice against acute systemic infections with Escherichia coli, Pseudomonas aeruginosa and Candida albicans, and intramuscular infection with Escherichia coli. The clearance of Escherichia coli from the blood of X-ray irradiated mice was also promoted by the treatment with Y-19995. The augmented protection against microbial infections in immunocompromised hosts by Y-19995 may be attributed mainly to the prevention of leukocytopenia or the enhanced restoration from leukocytopenia.
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Authors | H Fujisawa, S Tsuru, M Hisatome, K Goto, T Oe, T Okumoto, M Taniguchi, K Nomoto |
Journal | Journal of clinical & laboratory immunology
(J Clin Lab Immunol)
Vol. 23
Issue 4
Pg. 203-8
(Aug 1987)
ISSN: 0141-2760 [Print] Scotland |
PMID | 3312612
(Publication Type: Journal Article)
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Chemical References |
- Mitomycins
- Pyridines
- Y 19995
- Picibanil
- Cyclophosphamide
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Topics |
- Animals
- Bacterial Infections
(drug therapy, immunology)
- Bone Marrow
(drug effects)
- Bone Marrow Cells
- Candidiasis
(drug therapy, immunology)
- Cyclophosphamide
- Escherichia coli Infections
(drug therapy, immunology)
- Immunosuppression Therapy
- Leukocyte Count
(drug effects)
- Leukopenia
(chemically induced, drug therapy)
- Male
- Mice
- Mice, Inbred ICR
(radiation effects)
- Mitomycins
- Picibanil
(pharmacology)
- Pseudomonas Infections
(drug therapy, immunology)
- Pyridines
(administration & dosage, immunology, pharmacology)
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