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Short-course chemotherapy of pulmonary tuberculosis in pneumoconiotic patients.

Abstract
This is the first prospective clinical trial recorded to date of short-course chemotherapy in pulmonary tuberculosis complicated by pneumoconiosis. Forty-eight anthrasillicotic and 11 silicotic patients with previously untreated pulmonary tuberculosis completed 9-month, short-course chemotherapy regimens: 2 months of daily streptomycin, isoniazid, rifampicin, and pyrazinamide followed by daily isoniazid and rifampicin for 7 months (2SHRZ/7HR). There were 3 treatment failures (5%). The remaining 56 patients (95%) all had their sputum converted within 4 months (mean, 1.5 months). Bacteriologic relapses were noted in 3 patients (5%) after 18 to 40 months of follow-up (mean, 28.4 months). The relapses occurred within 7 months after chemotherapy was stopped. There were 2 deaths from nontuberculosis causes during the follow-up period. Fifty-one patients (90%) remained bacteriologically sterile for 28.4 +/- 6.1 months. These results suggest that the 2SHRZ/7HR regimen is satisfactory in treating anthrasilicotic or silicotic patients with pulmonary tuberculosis, though antituberculosis chemotherapy seemed less effective in patients with pneumoconiosis than in those without pneumoconiosis.
AuthorsT P Lin, J Suo, C N Lee, J J Lee, S P Yang
JournalThe American review of respiratory disease (Am Rev Respir Dis) Vol. 136 Issue 4 Pg. 808-10 (Oct 1987) ISSN: 0003-0805 [Print] United States
PMID3310770 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
Chemical References
  • Antitubercular Agents
  • Pyrazinamide
  • Isoniazid
  • Rifampin
  • Streptomycin
Topics
  • Adult
  • Aged
  • Antitubercular Agents (therapeutic use)
  • Clinical Trials as Topic
  • Drug Therapy, Combination
  • Humans
  • Isoniazid (administration & dosage)
  • Middle Aged
  • Pneumoconiosis (drug therapy)
  • Prospective Studies
  • Pyrazinamide (administration & dosage)
  • Recurrence
  • Rifampin (administration & dosage)
  • Streptomycin (administration & dosage)
  • Time Factors
  • Tuberculosis, Pulmonary (complications, drug therapy)

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