Abstract |
This is the first prospective clinical trial recorded to date of short-course chemotherapy in pulmonary tuberculosis complicated by pneumoconiosis. Forty-eight anthrasillicotic and 11 silicotic patients with previously untreated pulmonary tuberculosis completed 9-month, short-course chemotherapy regimens: 2 months of daily streptomycin, isoniazid, rifampicin, and pyrazinamide followed by daily isoniazid and rifampicin for 7 months (2SHRZ/7HR). There were 3 treatment failures (5%). The remaining 56 patients (95%) all had their sputum converted within 4 months (mean, 1.5 months). Bacteriologic relapses were noted in 3 patients (5%) after 18 to 40 months of follow-up (mean, 28.4 months). The relapses occurred within 7 months after chemotherapy was stopped. There were 2 deaths from nontuberculosis causes during the follow-up period. Fifty-one patients (90%) remained bacteriologically sterile for 28.4 +/- 6.1 months. These results suggest that the 2SHRZ/7HR regimen is satisfactory in treating anthrasilicotic or silicotic patients with pulmonary tuberculosis, though antituberculosis chemotherapy seemed less effective in patients with pneumoconiosis than in those without pneumoconiosis.
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Authors | T P Lin, J Suo, C N Lee, J J Lee, S P Yang |
Journal | The American review of respiratory disease
(Am Rev Respir Dis)
Vol. 136
Issue 4
Pg. 808-10
(Oct 1987)
ISSN: 0003-0805 [Print] United States |
PMID | 3310770
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Chemical References |
- Antitubercular Agents
- Pyrazinamide
- Isoniazid
- Rifampin
- Streptomycin
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Topics |
- Adult
- Aged
- Antitubercular Agents
(therapeutic use)
- Clinical Trials as Topic
- Drug Therapy, Combination
- Humans
- Isoniazid
(administration & dosage)
- Middle Aged
- Pneumoconiosis
(drug therapy)
- Prospective Studies
- Pyrazinamide
(administration & dosage)
- Recurrence
- Rifampin
(administration & dosage)
- Streptomycin
(administration & dosage)
- Time Factors
- Tuberculosis, Pulmonary
(complications, drug therapy)
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