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Effects of pentoxifylline on severe intermittent claudication.

Abstract
Pentoxifylline has been shown to improve treadmill walking distances under blinded, controlled conditions in patients with intermittent claudication. From the pooled data of a blinded, controlled, randomized, multicenter trial, the data from all enrolled patients with severe claudication (less than 70 m on treadmill at baseline) were evaluated. The treadmill data from these more severely ill patients were analyzed separately as a "severe subset" (placebo n = 17; pentoxifylline n = 21). No differences between the two treatment groups were observed in demography, history, or baseline treadmill walking distances. The initial claudication distance (ICD) improved 68% over baseline with pentoxifylline and 12% with placebo (p = .012) after twenty-four weeks of treatment. A new, derived efficacy variable was developed, "minimum distance walked," which tended to minimize psychological effects on treadmill performance. Over sixteen to twenty-four weeks of treatment, the pentoxifylline group improved 49% over baseline and the placebo group 3% (p = .019), when the "minimum distance walked" measurement was used. In this controlled trial the subset of patients with severe intermittent claudication benefited from pentoxifylline therapy.
AuthorsT Reich, D Gillings
JournalAngiology (Angiology) Vol. 38 Issue 9 Pg. 651-6 (Sep 1987) ISSN: 0003-3197 [Print] United States
PMID3310744 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Theobromine
  • Pentoxifylline
Topics
  • Aged
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Intermittent Claudication (drug therapy, physiopathology)
  • Locomotion
  • Male
  • Middle Aged
  • Pentoxifylline (administration & dosage, therapeutic use)
  • Random Allocation
  • Theobromine (analogs & derivatives)
  • Time Factors

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