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Famotidine: proven once-a-day treatment for gastric ulcer.

Abstract
An 8-week, double-blind, randomized, placebo-controlled, multinational (n = 14), multicenter (n = 44) trial was conducted to determine whether famotidine speeds healing and relief of symptoms in patients with benign gastric ulcer. Of the 336 patients who entered the trial, 167 received 40 mg of famotidine in the evening, and 169 received placebo. At 4, 6, and 8 weeks after entry, ulcers had healed in a significantly (P less than 0.01) higher percentage of famotidine-treated patients than in those treated with placebo (47%, 65%, 80% versus 31%, 46%, 54%, respectively). Famotidine was also superior to placebo in relieving ulcer symptoms; the proportion of patients receiving additional antacid therapy was significantly lower in the famotidine group. The findings show that the new H2-receptor antagonist famotidine, administered as a single evening dose, significantly speeds the healing of benign gastric ulcers and that it is a safe and highly effective treatment of gastric ulceration. The convenient dosage regimen of famotidine (one tablet in the evening) should improve patient compliance, which, in turn, may result in faster healing of ulcers and a lower incidence of ulcer complications.
AuthorsH G Dammann, T A Walter, E Hentschel, P Muller, B Simon
JournalScandinavian journal of gastroenterology. Supplement (Scand J Gastroenterol Suppl) Vol. 134 Pg. 29-33 ( 1987) ISSN: 0085-5928 [Print] England
PMID3310200 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Ulcer Agents
  • Thiazoles
  • Famotidine
Topics
  • Adult
  • Anti-Ulcer Agents (administration & dosage, adverse effects)
  • Clinical Trials as Topic
  • Double-Blind Method
  • Drug Administration Schedule
  • Famotidine
  • Female
  • Humans
  • Male
  • Middle Aged
  • Random Allocation
  • Stomach Ulcer (drug therapy)
  • Thiazoles (administration & dosage, adverse effects)

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