Abstract | BACKGROUND: METHODS: The synaptophysin levels were measured as a marker for neuron cell (neurogenesis) of brain nerve cells in Sprague-Dawley rats aged 10-12 weeks, weighing 200-300 g. All rats (n = 10) were performed as traumatic brain injury using The Modified Marmourou Model, then they were divided into 2 group, one group was given MLC901 (n = 5) and the other group was not given MLC901 (n = 5). The synaptophysin levels in both groups were assessed after 6 weeks and also carried out an examination of immnuhistochemical from the brain tissue of both groups. RESULTS: There was an increase in the number of neuron cells as evidenced by synaptophysin ihc staining in the rats given MLC 901 ( Neuroaid II) compared to those without MLC 901. Synaptophysin levels were lower in the control group than in the MLC 901 group (81.6, SD: 13.52 vs 118.4, SD: 12.198, p = 0.062). CONCLUSION:
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Authors | Rohadi Muhammad Rosyidi, Bambang Priyanto, Andi Asadul Islam, Mochammad Hatta, Agussalim Bukhari, Krisna Tsaniadi Prihastomo, Rizha Anshori Nasution, Rozikin, Lale Maulin Prihatina |
Journal | Annals of medicine and surgery (2012)
(Ann Med Surg (Lond))
Vol. 60
Pg. 36-40
(Dec 2020)
ISSN: 2049-0801 [Print] England |
PMID | 33101671
(Publication Type: Journal Article)
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Copyright | © 2020 The Author(s). |