Abstract | PURPOSE: METHODS: Between January 2015 and December 2017, the patients with primary non-small cell lung cancer who underwent lobectomy and SLND were retrospectively reviewed. Patients in the prophylactic group started fat-free diet one week before the surgery until removal of the chest tubes after the operation; while those in the control group took normal diet unless the onset of chylothorax. Logistic regression analysis was utilized to identify the predictive factors of chylothorax following lobectomy. RESULTS: The data of 110 patients in the control group and 115 cases in the prophylactic group were collected. The patients in prophylactic group showed less intraoperative blood loss [(79.9±48.7) mL vs. (100.9±55.6) mL, p=0.003], reduced postoperative drainage volume [(504.3±268.0) mL vs. (714.1±618.5) mL, p=0.001], and shorter chest tube duration [(3.6±1.7) days vs. (4.2±2.6) days, p=0.014]; however, a similar incidence of chylothorax [3 (2.6%) vs. 7 (6.4%), p=0.207] was recorded. Multivariate logistic regression analysis indicated that neoadjuvant therapy was an independent positive factor of chylothorax (odd ratio [OR] = 9.257; 95% confidence interval [CI] 1.434-59.773, p=0.019); whereas high-volume experience of the surgeon was an independent negative factor of this complication (OR = 0.129; 95% CI 0.017-0.982, p=0.048). CONCLUSION: Prophylactic fat-free diet does not decrease the incidence of chylothorax after lobectomy. Further well-designed trials are warranted to verify this occasional finding.
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Authors | Miao Zhang, Wenbin Wu, Ruoran Li, Min Wang, Dunpeng Yang, Dong Liu, Yanmin Wu, Ying Wu, Ning Chai |
Journal | Journal of B.U.ON. : official journal of the Balkan Union of Oncology
(J BUON)
2020 Jul-Aug
Vol. 25
Issue 4
Pg. 1753-1760
ISSN: 2241-6293 [Electronic] Cyprus |
PMID | 33099910
(Publication Type: Journal Article)
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Topics |
- Case-Control Studies
- Chylothorax
(etiology, pathology)
- Diet, Fat-Restricted
- Female
- Humans
- Lung Neoplasms
(complications, surgery)
- Male
- Middle Aged
- Pneumonectomy
(adverse effects, methods)
- Postoperative Period
- Retrospective Studies
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