Atypical Central Neurocytoma: An Investigation of Prognostic Factors.

Abstract

OBJECTIVE:

Central neurocytoma is a rare nervous tissue benign neoplasm. A subset of central neurocytoma has unfamiliar aggressive tendency: so-called atypical central neurocytoma (ACN). This retrospective study aims to analyze the prognostic factors and the impact of various therapy tools on atypical central neurocytoma.

METHODS:

Twenty-two patients diagnosed with ACN between January 2009 and March 2018 were included. Data collected included the patient's age, gender, tumor location, presenting symptoms, and treatment received. Patients were followed up to detect recurrence and to assess survival.

RESULTS:

Median overall survival was 57 months, with a 5-year survival of 35%. Better survival was observed for patients <35 years old (66 vs. 47 months; P = 0.061) and patients with gross total resection over subtotal resection or biopsy (76, 45, and 22 months, respectively; P < 0.0001). Patients with a tumor located in the posterior half of the lateral ventricle had better survival, with no statistical significance (P = 0.053). Multivariate analysis showed prognostic significance with the extent of resection (P = 0.000). Progression-free survival ranged from 6 to 82 months, with a median value of 38 months and showed a significant relation with subtotal resection compared with biopsy (P = 0.006). Recurrence was less in patients who received radiotherapy and was statistically significant (P = 0.007).

CONCLUSIONS:

Long-term survival is possible for patients with atypical central neurocytomas treated with surgery and postoperative radiation. Multivariate analysis confirmed that gross total resection was an independent prognostic factor for survival. Adjuvant radiotherapy reduces tumor recurrence, especially after incomplete surgery.

• Authors: Mohamed AbdelBari Mattar, Abdelhadi M Shebl, Eman A Toson
• Journal: World neurosurgery (World Neurosurg) Vol. 146 Pg. e184-e193 (02 2021) ISSN: 1878-8769 [Electronic] United States
• PMID: 33091649 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Elsevier Inc. All rights reserved.

Topics

• Adult
• Brain Neoplasms (mortality, surgery)
• Combined Modality Therapy (methods)
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Recurrence, Local (diagnosis, mortality, surgery)
• Neurocytoma (diagnosis, mortality, surgery)
• Prognosis
• Radiotherapy, Adjuvant (methods)
• Retrospective Studies
• Young Adult