Elevation of urinary trehalase activity in patients of itai-itai disease.

Abstract

The elevation of urinary trehalase activity in patients of itai-itai disease was examined. Urinary trehalase was correlated with tubular reabsorption of phosphorus (%TRP): the lower the trehalase activity, the worse was %TRP. Furthermore, this activity was inversely correlated with urinary glucose and urinary total protein. In itai-itai disease, the excretion of beta 2-microglobulin seems to be maximal, and urinary trehalase activity was low in the latter stages of the disease. It is inferred that itai-itai disease produces extremely severe tubular damage as well as glomerular dysfunction.

• Authors: M Nakano, K Aoshima, T Katoh, H Teranishi, M Kasuya
• Journal: Archives of toxicology (Arch Toxicol) Vol. 60 Issue 4 Pg. 300-3 (Jun 1987) ISSN: 0340-5761 [Print] Germany
• PMID: 3307705 (Publication Type: Journal Article)

Chemical References

• beta 2-Microglobulin
• Cadmium
• Alkaline Phosphatase
• Trehalase
• Leucyl Aminopeptidase

Topics

• Aged
• Aged, 80 and over
• Alkaline Phosphatase (urine)
• Cadmium (urine)
• Cadmium Poisoning (enzymology, urine)
• Female
• Glycosuria (urine)
• Humans
• Leucyl Aminopeptidase (urine)
• Middle Aged
• Proteinuria (chemically induced)
• Trehalase (urine)
• beta 2-Microglobulin (urine)