Loperamide in treatment of irritable bowel syndrome--a double-blind placebo controlled study.

Abstract

The effects of loperamide in patients with IBS (all had diarrhoea as a main symptom) were studied in a double-blind placebo controlled trial. Subjective overall response stool consistency and six individual symptoms (urgency, pain, frequency, flatulence, borborygmi and painful propulsions) were studied over a 13 week long treatment period. Twenty-one patients out of 25 completed the trial, 11 in the loperamide group and 10 in the placebo group. A significant advantage for loperamide was found for stool consistency (p less than 0.001), pain (p less than 0.02) and urgency (p less than 0.05). Subjective overall response was also significantly better in the loperamide group (p less than 0.03). Self-titration of dose and administration in a single nightly dose was safe and efficient.

• Authors: B Lavö, M Stenstam, A L Nielsen
• Journal: Scandinavian journal of gastroenterology. Supplement (Scand J Gastroenterol Suppl) Vol. 130 Pg. 77-80 ( 1987) ISSN: 0085-5928 [Print] England
• PMID: 3306903 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Piperidines
• Loperamide

Topics

• Adolescent
• Adult
• Aged
• Clinical Trials as Topic
• Colonic Diseases, Functional (drug therapy)
• Diarrhea (drug therapy)
• Double-Blind Method
• Female
• Humans
• Loperamide (adverse effects, therapeutic use)
• Male
• Middle Aged
• Patient Compliance
• Piperidines (therapeutic use)
• Random Allocation