Studies of immunosuppressive drugs in the treatment of lupus nephritis.

Abstract

Long-term, controlled trials to evaluate the efficacy and toxicities of immunosuppressive drug therapies compared to treatment with corticosteroids alone in the management of patients with lupus nephritis have been performed. The studies demonstrate that immunosuppressive drug regimens, particularly intravenous cyclophosphamide, reduce the likelihood of end-stage renal failure. However, toxicities such as herpes zoster and ovarian failure were found to be increased in patients with cyclophosphamide.

• Authors: J H Klippel, H A Austin 3rd, J E Balow, N G leRiche, A D Steinberg, P H Plotz, J L Decker
• Journal: Rheumatic diseases clinics of North America (Rheum Dis Clin North Am) Vol. 13 Issue 1 Pg. 47-56 (Apr 1987) ISSN: 0889-857X [Print] United States
• PMID: 3306824 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Immunosuppressive Agents

Topics

• Child
• Follow-Up Studies
• Humans
• Immunosuppressive Agents (adverse effects, therapeutic use)
• Kidney Transplantation
• Lupus Nephritis (drug therapy)
• Renal Dialysis