CGRP-Mediated Prolactin Upregulation: a Possible Pathomechanism in IgG4-Related Disease.

Abstract

Similar to other immune-mediated diseases, IgG4-related disease (IgG4-RD) is the disease that develops in genetically susceptible individuals exposed to external or endogenous antigens. In the present study, it was confirmed that MAG (myelin-associated glycoprotein) antibodies (IgG, IgG4, and IgM) were detected by immunofluorescence (IFA) in serum of the patients with IgG4-RD. In vivo, the levels of prolactin and Th2 cytokines in CGRP+/- rats were higher than those in wild-type. Our findings indicate that the presence of CGRP-deficiency-mediated MAG antibodies is a probable molecular basis for the initial events which were triggered in IgG4-RD immune responses via prolactin upregulation.

• Authors: Qicai Liu, Yunfeng Lin, Sheng Zhang, Min Chen, Qingquan Chen, Hongbin Rui, Fang Wang, Xiaoting Lv, Feng Gao
• Journal: Inflammation (Inflammation) Vol. 44 Issue 2 Pg. 536-548 (Apr 2021) ISSN: 1573-2576 [Electronic] United States
• PMID: 33067662 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• Biomarkers
• Cytokines
• Immunoglobulin G
• Immunoglobulin M
• Myelin-Associated Glycoprotein
• Prolactin
• Calcitonin Gene-Related Peptide

Topics

• Animals
• Autoantibodies (blood)
• Biomarkers (metabolism)
• Calcitonin Gene-Related Peptide (deficiency, genetics, immunology, metabolism)
• Case-Control Studies
• Computational Biology
• Cytokines (immunology, metabolism)
• Gene Knockdown Techniques
• Healthy Volunteers
• Humans
• Immunoglobulin G (blood)
• Immunoglobulin G4-Related Disease (genetics, immunology, metabolism)
• Immunoglobulin M (blood)
• Male
• Myelin-Associated Glycoprotein (immunology)
• Prolactin (immunology, metabolism)
• Rats
• Th2 Cells (immunology, metabolism)
• Up-Regulation