Abstract | BACKGROUND AND PURPOSE: METHODS: Two Chinese anti-NMDAR encephalitis cohorts from Han populations were recruited for this study. The North Chinese case-control set consisted of 98 patients and 460 controls, while the South Chinese case-control set included 78 patients and 541 controls. All participants were genotyped for 28 single nucleotide polymorphisms that are associated with autoimmune disorders or infectious diseases. RESULTS: In two independent case-control sets, we identified significant associations of anti-NMDAR encephalitis with IRF7 rs1131665 (odds ratio [OR] 3.34, 95% confidence interval [CI] 1.99-5.63; P < 0.000001, Padjusted = 0.00004), BANK1 rs4522865 (OR 1.44, 95% CI 1.15-1.82; P = 0.0017, Padjusted = 0.0149), and TBX21 rs17244587 (OR 2.03, 95% CI 1.35-3.05; P = 0.00051, Padjusted = 0.0066). Furthermore, analysis of the three polymorphisms with clinical features of the disease revealed that the IRF7 rs1131665 was associated with tumor status. CONCLUSION:
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Authors | Y Shu, J Guo, X Ma, Y Yan, Y Wang, C Chen, X Sun, H Wang, J Yin, Y Long, X Yan, Z Lu, F Petersen, X Yu, W Qiu |
Journal | European journal of neurology
(Eur J Neurol)
Vol. 28
Issue 2
Pg. 595-601
(02 2021)
ISSN: 1468-1331 [Electronic] England |
PMID | 33065758
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2020 European Academy of Neurology. |
Chemical References |
- Adaptor Proteins, Signal Transducing
- Autoantibodies
- BANK1 protein, human
- IRF7 protein, human
- Interferon Regulatory Factor-7
- Membrane Proteins
- Receptors, N-Methyl-D-Aspartate
- T-Box Domain Proteins
- T-box transcription factor TBX21
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Topics |
- Adaptor Proteins, Signal Transducing
- Anti-N-Methyl-D-Aspartate Receptor Encephalitis
(genetics)
- Autoantibodies
- Case-Control Studies
- Humans
- Interferon Regulatory Factor-7
(genetics)
- Membrane Proteins
- Receptors, N-Methyl-D-Aspartate
(genetics)
- T-Box Domain Proteins
(genetics)
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