Pathology of growth hormone-producing tumors of the human pituitary.

Abstract

This paper reviews the morphologic features of growth hormone-producing tumors of the human pituitary. These tumors are associated with elevated blood growth hormone levels and acromegaly or gigantism and can be classified into the following morphologically distinct entities by the combined application of histology, immunocytology, and electron microscopy: densely granulated growth hormone cell adenoma; sparsely granulated growth hormone cell adenoma; mixed growth hormone cell- prolactin cell-adenoma; acidophil stem cell adenoma; mammosomatotroph cell adenoma; growth hormone cell carcinoma; plurihormonal adenoma with growth hormone production.

• Authors: K Kovacs, E Horvath
• Journal: Seminars in diagnostic pathology (Semin Diagn Pathol) Vol. 3 Issue 1 Pg. 18-33 (Feb 1986) ISSN: 0740-2570 [Print] United States
• PMID: 3303228 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Prolactin
• Growth Hormone

Topics

• Adenoma (metabolism, pathology)
• Cytoplasmic Granules (ultrastructure)
• Exocytosis
• Growth Hormone (metabolism)
• Humans
• Immunoenzyme Techniques
• Microscopy, Electron
• Pituitary Gland (pathology)
• Pituitary Neoplasms (metabolism, pathology)
• Prolactin (metabolism)