EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.

Abstract

Eukaryotic translation elongation factor 1δ (EEF1D), a subunit of the elongation factor 1 complex of proteins, mediates the elongation process of protein synthesis. Besides this canonical role, EEF1D was found overexpressed in many tumors, like hepatocarcinomas and medulloblastomas. In the present study, we demonstrated for the first time that EEF1D may interact with other putative proteins to regulate cell proliferation, migration, and invasion through PI3K/Akt and EMT pathways in glioma. Furthermore, knockdown of EEF1D could reduce cell proliferation and impaired epithelial-mesenchymal transition (EMT) phenotypes, including cell invasion. Taken together, these results indicate that EEF1D and its partner proteins might play a critical role in glioma and serve as a potential therapeutic target of glioma.

• Authors: Cheng Xie, Mingfeng Zhou, Jie Lin, Zhiyong Wu, Shengfeng Ding, Jie Luo, Zhengming Zhan, Yonghua Cai, Shuaishuai Xue, Ye Song
• Journal: BioMed research international (Biomed Res Int) Vol. 2020 Pg. 7804706 ( 2020) ISSN: 2314-6141 [Electronic] United States
• PMID: 33029523 (Publication Type: Journal Article)
• Copyright: Copyright © 2020 Cheng Xie et al.

Chemical References

• Biomarkers, Tumor
• EEF1D protein, human
• Peptide Elongation Factor 1
• RNA, Messenger
• Proto-Oncogene Proteins c-akt

Topics

• Biomarkers, Tumor (metabolism)
• Brain Neoplasms (genetics, pathology)
• Cell Line, Tumor
• Cell Movement
• Cell Proliferation
• Epithelial-Mesenchymal Transition
• Gene Expression Regulation, Neoplastic
• Gene Knockdown Techniques
• Glioma (genetics, pathology)
• Humans
• Neoplasm Grading
• Neoplasm Invasiveness
• Peptide Elongation Factor 1 (genetics, metabolism)
• Phosphatidylinositol 3-Kinases (metabolism)
• Protein Binding
• Proto-Oncogene Proteins c-akt (metabolism)
• RNA, Messenger (genetics, metabolism)
• Signal Transduction