[Clinical trial of forphenicinol for the lung infection with Mycobacterium avium, Mycobacterium intracellulare complex].
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| Abstract |
Clinical evaluation of forphenicinol, a low molecular weight immunomodulator, in patients with Mycobacterium avium, Mycobacterium intracellulare complex pulmonary infections has been conducted in a multicenter trial participated by 9 institutions in Kyushu during a period of 12 months from July 1982 to August 1983. Forphenicinol was administered for 6 months without changing the regimen of antituberculous drugs used previously. The following results were obtained. 1. Ten out of 33 eligible patients were evaluated as showing good responses; In 5 of them, elimination of M. avium, M. intracellulare complex from sputum was observed. In the other 5 patients, number of bacilli excreted was decreased significantly after treatment. 2. All of the cases with good responses were those which were simultaneously administered with antituberculous drugs. 3. Patients with thick-walled cavities, following cured tuberculosis, which was superimposed with M. avium, M. intracellulare complex, were poorly responded to forphenicinol. 4. Side effects were observed in 3 out of 41 patients; 1 case each with fever, abdominal distension and anorexia. No abnormalities in laboratory test values were observed.
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| Authors | T Ishibashi, M Takamoto, A Shinoda, H Kihara, H Nagano, K Kawakami, Y Yamato, K Nakanishi, T Yamamoto, T Otsu |
| Journal | The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 40 Issue 4 Pg. 711-26 (Apr 1987) ISSN: 0368-2781 [Print] Japan |
| PMID | 3302344 (Publication Type: Clinical Trial, English Abstract, Journal Article) |
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