Clinical efficacy of listerine in inhibiting and reducing plaque and experimental gingivitis.

103 adult subjects completed a supervised 2-week double-blind controlled clinical study to determine the effect of using either listerine antiseptic (LA) or its vehicle control (VC), as the only oral hygiene procedure, in inhibiting the development of and in reducing plaque and experimental gingivitis. Following baseline examinations, half-mouth prophylaxes were performed on each subject, who continued normal oral hygiene and returned 4 or 5 days later for a second baseline. Subjects then rinsed, under supervision, either 2 or 4 times daily for 2 weeks with LA or twice daily with VC, but suspended all other oral hygiene measures. Plaque and gingivitis were evaluated at baselines and after 2 weeks. Subjects using LA 2 or 4 times a day as the only oral hygiene procedure for 2 weeks demonstrated highly significant inhibition and reduction of both supragingival plaque and gingival inflammation compared to those using VC.
AuthorsS Mankodi, N M Ross, K Mostler
JournalJournal of clinical periodontology (J Clin Periodontol) Vol. 14 Issue 5 Pg. 285-8 (May 1987) ISSN: 0303-6979 [Print] DENMARK
PMID3301915 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Anti-Infective Agents, Local
  • Mouthwashes
  • Adolescent
  • Adult
  • Anti-Infective Agents, Local (administration & dosage, therapeutic use)
  • Clinical Trials as Topic
  • Dental Plaque (prevention & control)
  • Double-Blind Method
  • Female
  • Gingivitis (prevention & control)
  • Humans
  • Male
  • Middle Aged
  • Mouthwashes (therapeutic use)
  • Random Allocation

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: