Abstract | PURPOSE: METHODS: Patients diagnosed between 2004 and 2015 with non-metastatic vaginal cancer treated with definitive CHT and external beam radiotherapy with or without BT but with no surgery were identified in the National Cancer Database. Overall survival (OS) was assessed with Kaplan-Meier curves, and differences between groups were compared with the log-rank test. A Cox model was constructed to evaluate survival after controlling for confounders. A Cox model using a penalized spline function was constructed to evaluate how the length of radiation therapy correlated with OS among patients receiving BT. RESULTS: A total of 1094 patients who met the inclusion criteria were identified. The utilization of BT was associated with improved 5-year OS (62.9% vs. 49.3%, p = 0.0126) on propensity score-weighted analyses. TTC of 63 days or less was associated with improved 5-year OS (67.8% vs. 54.5%, p = 0.0031) in patients who underwent BT. Other factors associated with improved OS in patients who received CHT, external beam radiotherapy, and BT were younger age, absent comorbidity score, and negative lymph nodes. CONCLUSIONS:
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Authors | Leonid B Reshko, Jeremy T Gaskins, Daniel S Metzinger, Sarah L Todd, Harriet B Eldredge-Hindy, Scott R Silva |
Journal | Brachytherapy
(Brachytherapy)
2021 Jan-Feb
Vol. 20
Issue 1
Pg. 75-84
ISSN: 1873-1449 [Electronic] United States |
PMID | 33008762
(Publication Type: Journal Article)
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Copyright | Copyright © 2021 American Brachytherapy Society. Published by Elsevier Inc. All rights reserved. |
Topics |
- Brachytherapy
(methods)
- Chemoradiotherapy
- Duration of Therapy
- Female
- Humans
- Neoplasm Staging
- Retrospective Studies
- Vaginal Neoplasms
(radiotherapy)
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