HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Results from the first 2 years of a clinical trial with recombinant DNA-derived human growth hormone (somatrem) in Turner's syndrome.

Abstract
A total of 70 subjects with Turner's syndrome from 11 centres were enrolled in a study of somatrem. After an initial observation period, they were randomly assigned to one of four groups, receiving no treatment (Group 1, control); oxandrolone, 0.125 mg/kg/day (Group 2); somatrem, 0.125 mg/kg 3 times/week (Group 3); or a combination of somatrem and oxandrolone on the above dose regimens (Group 4). After 12-20 months, Groups 1 (control), 2 (oxandrolone) and 4 (combination) were treated with somatrem, 0.125 mg/kg 3 times/week, and oxandrolone, 0.0625 mg/kg/day; Group 3 remained on somatrem, 0.125 mg/kg 3 times/week. All three treatment groups showed a statistically significant increase during year 1 in growth velocity over both their pretreatment growth rates and the control group growth rate. These increases were slightly less in year 2 for the somatrem and combination therapy groups, but remained significantly higher than the year 1 control group growth rate. Plasma IGF-1 levels were elevated in years 1 and 2 in the somatrem and combination groups. Adverse events were few with the somatrem group, though mild virilization occurred with oxandrolone, alone or in combination. Bone age advancement was observed with all treatments but was greater with combination therapy; it was accompanied by height age advancement. The effect of this therapy on predicted adult height was also evaluated.
AuthorsR G Rosenfeld, R L Hintz, A J Johanson, B Sherman
JournalActa paediatrica Scandinavica. Supplement (Acta Paediatr Scand Suppl) Vol. 331 Pg. 59-69 ( 1987) ISSN: 0300-8843 [Print] Sweden
PMID3300157 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Hormones
  • Recombinant Proteins
  • Human Growth Hormone
  • Insulin-Like Growth Factor I
  • Oxandrolone
  • Growth Hormone
Topics
  • Age Determination by Skeleton
  • Child
  • Child, Preschool
  • Clinical Trials as Topic
  • Drug Therapy, Combination
  • Female
  • Growth
  • Growth Hormone (adverse effects, analogs & derivatives, therapeutic use)
  • Hormones (therapeutic use)
  • Human Growth Hormone
  • Humans
  • Insulin-Like Growth Factor I (blood)
  • Kinetics
  • Oxandrolone (therapeutic use)
  • Prognosis
  • Recombinant Proteins (adverse effects, therapeutic use)
  • Turner Syndrome (drug therapy, physiopathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: