A bolus/basal multiple injection regimen in type I diabetes. A multicentre trial using a new 'fountain-pen' device for short-acting human insulin as well as long-acting human insulin.

Abstract

A trial was undertaken to ascertain the effect and acceptability of a multiple insulin injection regimen (MII) in patients with insulin-dependent diabetes mellitus using short-acting monocomponent human soluble insulin (Actrapid HM; Novo) for pre-meal bolus injections with the NovoPen injection device (Novo) and long-acting human insulin (Ultratard HM; Novo) at bedtime. Fifty-four patients, all previously on twice-daily short/intermediate-acting human insulin (Monotard HM; Novo) and Actrapid HM, were randomly selected. There was a significant overall improvement in diabetic control over the 12 weeks of the trial, the glycosylated haemoglobin (Hb A1) dropping from a mean of 9.8 +/- 2.2% to 8.6 +/- 1.7% (P less than 0.05). MII, using the NovoPen, was found to be more convenient than conventional insulin administration by 92% of the subjects. It is concluded that the NovoPen is a useful and convenient means of administering pre-meal boluses in an MII regimen, with a very high rate of acceptance by patients of all ages.

• Authors: L A Distiller, L I Robertson, R Moore, F Bonnici
• Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 71 Issue 12 Pg. 749-52 (Jun 20 1987) ISSN: 0256-9574 [Print] South Africa
• PMID: 3299758 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Glycated Hemoglobin A
• Insulin
• Insulin, Long-Acting

Topics

• Adolescent
• Adult
• Child
• Clinical Trials as Topic
• Diabetes Mellitus, Type 1 (drug therapy)
• Evaluation Studies as Topic
• Female
• Glycated Hemoglobin (analysis)
• Humans
• Injections (instrumentation)
• Insulin (administration & dosage)
• Insulin, Long-Acting (administration & dosage)
• Male
• Middle Aged
• Random Allocation
• Time Factors