[Cyclophosphamide and total lymph node irradiation as conditioning for bone marrow transplant in severe aplastic anemia].

Abstract

Personal experience is outlined with a preparative regimen consisting of total nodal irradiation (TNI) and cyclophosphamide in patients with severe aplastic anemia undergoing bone marrow transplantation (BMT). Nine patients (median age 23) previously having blood transfusions received BMT at the BMT Center in Pesaro. All patients were prepared for transplantation with cyclophosphamide 50 mg/kg/day (day -6, -5, -4, -3), and 7.5 Gy total nodal irradiation day -1, with a dose rate of 26 cGy/m. Six out of eight evaluable transplanted patients are still surviving 3 to 23 months with a median follow-up of 16.5 months. This preoperative regimen is extremely effective in decreasing rejection following transplantation for severe aplastic anemia. Future investigation must be aimed at the elimination of graft-versus-host-disease and control of fatal infections.

• Authors: G Sotti, A Rigon, C Polico, G Scarzello, M L Friso, F Calzavara, R Fabbris, C Cauzzo
• Journal: La Radiologia medica (Radiol Med) Vol. 73 Issue 6 Pg. 545-6 (Jun 1987) ISSN: 0033-8362 [Print] Italy
• Vernacular Title: Ciclofosfamide (CTX) ed irradiazione linfonodale totale (TNI) come condizionamento al trapianto di midollo osseo (BMT) nelle anemie aplastiche gravi (AAG).
• PMID: 3299513 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cyclophosphamide

Topics

• Acute Disease
• Adolescent
• Adult
• Anemia, Aplastic (therapy)
• Bone Marrow Transplantation
• Child
• Child, Preschool
• Cyclophosphamide (therapeutic use)
• Female
• Humans
• Lymph Nodes (radiation effects)
• Male
• Preoperative Care
• Radiotherapy Dosage