Abstract | PURPOSE:
Chemotherapy is a comprehensive therapy for breast cancer; nevertheless, its associated adverse effects are drawing increasing attention with the continuous improvement of the efficacy. The changes in serum lipids of breast cancer patients caused by chemotherapy have been reported by previous studies, whereby the former increase the incidence rate of cardiovascular disorders. However, the variations in the changes of serum lipids with different chemotherapy regimens have seldom been reported. METHODS: RESULTS: It was observed that the levels of TG, TC, LDL-C and Lpa increased significantly while that of HDL-C decreased after adjuvant chemotherapy in breast cancer patients (P<0.05). Besides, dose-dense regimens had more influence in TG and HDL-C and less influence in TC and LDL-C than standard-interval regimens. HDL-C was more sensitive to anthracycline-based regimens than taxane-based regimens. The level of TG with anthracycline-plus- taxane-based regimens was higher than that with only anthracycline-based or taxane-based regimens, and the level of HDL-C with anthracycline-plus- taxane-based regimen showed lower than that with taxane-based regimen. CONCLUSION:
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Authors | Qi Lu, Xian Wu, Yanhui Zhu, Junzhe Yang, Xingmeng Wang, Chaoran Ye, Ruyu Cai, Kai Zhang, Tingyu Xu, Bing Wang, Jordee S Veeramootoo, Tiansong Xia, Xiaoan Liu |
Journal | Cancer management and research
(Cancer Manag Res)
Vol. 12
Pg. 8397-8408
( 2020)
ISSN: 1179-1322 [Print] New Zealand |
PMID | 32982433
(Publication Type: Journal Article)
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Copyright | © 2020 Lu et al. |