Abstract | OBJECTIVES: MATERIALS AND METHODS: In this multicenter study, consecutive NPC patients (n = 3166) who underwent definitive IMRT in all six public oncology centers in Hong Kong between 2001 and 2010 were included. SPC risks were quantified by standardized incidence ratios (SIRs) and absolute excess risks (AERs) estimated from corresponding age-, sex-, and calendar year-specific population cancer incidence data from the Hong Kong Cancer Registry. Predictive factors and SPC-specific mortality were analyzed. RESULTS: Over a median follow-up period of 10.8 years, 290 cases of SPC were observed with a crude incidence of 9.2%. Cancer risk in NPC survivors was 90% higher than that in general population [SIR, 1.9; 95% confidence interval (CI), 1.7-2.2], with an AER of 52.1 (95% CI, 36.8-67.3) per 10,000 person-years at risk. Significant excess cancer risks were observed for oral cavity, sarcoma, oropharynx, paranasal sinus, salivary gland, thyroid, skin and lung. Advanced age, smoking, hepatitis B status, and re-irradiation were independent predictive factors. SPC accounted for 9.4% of all deaths among NPC survivors during the study period, and 10-year SPC-specific mortality was 3.4%. CONCLUSIONS:
Second cancer risk after IMRT was substantial among NPC patients. SPC impairs long-term survival, and close surveillance is warranted as part of survivorship care.
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Authors | James C H Chow, Anthony H P Tam, Ka-Man Cheung, Victor H F Lee, Chi-Leung Chiang, Macy Tong, Edwin C Y Wong, Alice K W Cheung, Sunny P C Chan, Jessica W Y Lai, Roger K C Ngan, Wai-Tong Ng, Anne W M Lee, Kwok-Hung Au |
Journal | Oral oncology
(Oral Oncol)
Vol. 111
Pg. 105012
(12 2020)
ISSN: 1879-0593 [Electronic] England |
PMID | 32980659
(Publication Type: Journal Article, Multicenter Study)
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Copyright | Copyright © 2020 Elsevier Ltd. All rights reserved. |
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Female
- Hong Kong
(epidemiology)
- Humans
- Incidence
- Male
- Middle Aged
- Nasopharyngeal Carcinoma
(mortality, radiotherapy)
- Nasopharyngeal Neoplasms
(mortality, radiotherapy)
- Neoplasms, Second Primary
(epidemiology, mortality)
- Radiotherapy, Intensity-Modulated
(adverse effects)
- Risk Assessment
- Smokers
- Young Adult
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