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Intrahepatic cholestasis in acute viral hepatitis: a double-blind trial with dihydroxydibutylether in comparison with placebo.

Abstract
The authors studied the effectiveness of a choleretic drug, dihydroxydibutylether (DHBE), 900 mg daily, in patients with acute viral hepatitis and intrahepatic cholestasis. The four-week, double-blind and placebo-controlled trial showed a more rapid return to normal bilirubin and fasting and post-prandial biliary acid values and plasma transaminases levels in the DHBE-treated group of patients.
AuthorsG Marchettini, P Corsini, G Massimini
JournalDrugs under experimental and clinical research (Drugs Exp Clin Res) Vol. 13 Issue 1 Pg. 51-6 ( 1987) ISSN: 0378-6501 [Print] Switzerland
PMID3297594 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
Chemical References
  • Bile Acids and Salts
  • Cholagogues and Choleretics
  • Ethers
  • 4,4'-oxydi-2-butanol
Topics
  • Adolescent
  • Adult
  • Aged
  • Bile Acids and Salts (analysis)
  • Cholagogues and Choleretics (therapeutic use)
  • Cholestasis, Intrahepatic (complications, drug therapy)
  • Clinical Trials as Topic
  • Double-Blind Method
  • Ethers (therapeutic use)
  • Female
  • Hepatitis, Viral, Human (complications, drug therapy)
  • Humans
  • Liver Function Tests
  • Male
  • Middle Aged

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