A bioglass sustained-release scaffold with ECM-like structure for enhanced diabetic wound healing.

Abstract

Aim: To develop an effective strategy for increasing angiogenesis at diabetic wound sites and thereby accelerating wound healing. Materials & methods: A micropatterned nanofibrous scaffold with bioglass nanoparticles encapsulated inside coaxial fibers was prepared by electrospinning. Results: Si ions could be released in a sustained manner from the scaffolds. The hierarchical micro-/nano-structure of the scaffold was found to act as a temporary extracellular matrix to promote endothelial cell adhesion and growth. The scaffold greatly improved angiogenesis and collagen deposition at the wound site, which shortened the healing period of diabetic wounds. Conclusion: This study provides a promising therapeutic option for chronic diabetic wounds with improved angiogenesis.

• Authors: Pengju Zhang, Yuqi Jiang, Dan Liu, Yan Liu, Qinfei Ke, He Xu
• Journal: Nanomedicine (London, England) (Nanomedicine (Lond)) Vol. 15 Issue 23 Pg. 2241-2253 (08 2020) ISSN: 1748-6963 [Electronic] England
• PMID: 32967568 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bioglass
• Delayed-Action Preparations

Topics

• Ceramics
• Delayed-Action Preparations
• Diabetes Mellitus
• Extracellular Matrix
• Humans
• Nanofibers
• Tissue Scaffolds
• Wound Healing