Abstract | OBJECTIVE: METHODS: RESULTS: Compared with the blank control group, the escape latency of the rats in the model group increased from day 2 to day 5 (P<0.01), and the ratio of the time through the quadrant of the original platform reduced (P<0.01), in the open field test the distance of exercise, the number of uprights and the rate of exercise time in the central area decreased (P<0.01), meanwhile the density of hippocampus synapses decreased (P<0.01), the positive expression of PHF-1 and the relative expression of PI3K, AKT, p-AKT, and mTOR all increased (P<0.01). Compared with the model group, the escape latency of rats in the electroacupuncture group was shortened from day 2 to day 5 (P<0.01), and the ratio of the time through the quadrant of the original platform meanwhile, the distance of the open field test, the number of uprights, and the rate of central area exercise time up-regulated (P<0.01), the numerical density of hippocampus synatic increased (P<0.01), the positive expression of PHF-1 and the relative expression of PI3K, AKT, p-AKT, and mTOR all down-regulated (P<0.01). Compared with the model group, the expression of PI3K in the sham electroacupuncture group decreased (P<0.05). CONCLUSION:
Electroacupuncture can improve learning and memory and cognitive impairment in AD rats, which may be associated with its effects in regulation of hippocampal autophagy and removal of neurofibrillary tangles by suppressing PI3K/AKT/mTOR signaling pathway.
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Authors | Qing Zheng, Li-Hong Kong, Chao-Chao Yu, Rui-Yang He, Xue-Song Wang, Tao Jiang, Ran Ma, Yun-Yun Chen, Yue-Shen Wang |
Journal | Zhen ci yan jiu = Acupuncture research
(Zhen Ci Yan Jiu)
Vol. 45
Issue 9
Pg. 689-95
(Sep 25 2020)
ISSN: 1000-0607 [Print] China |
PMID | 32959549
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Alzheimer Disease
(genetics, therapy)
- Animals
- Autophagy
- Cognition
- Electroacupuncture
- Galactose
- Hippocampus
- Male
- Phosphatidylinositol 3-Kinases
- Rats
- Rats, Sprague-Dawley
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