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Pharmacological properties of besulpamide, a new diuretic, in rats and dogs.

Abstract
Besulpamide, a newly synthesized compound, has demonstrated significant diuretic activity in rats and dogs, similar to that of chlorthalidone, clopamide and xipamide. Antihypertensive activity of besulpamide is similar to that of hydrochlorothiazide and was demonstrated in rat one-kidney desoxycorticosterone acetate (DOCA)-salt hypertension. In addition, besulpamide, like hydrochlorothiazide, potentiated the antihypertensive activity of captopril in spontaneously hypertensive rats (SHR). Doses of besulpamide exceeding those normally required for pharmacological activity did not evoke adverse reactions in rats and mice.
AuthorsM Colombo, A J Farré, M Fort, L Martínez, R Roser, R Sagarra
JournalMethods and findings in experimental and clinical pharmacology (Methods Find Exp Clin Pharmacol) Vol. 9 Issue 2 Pg. 101-10 (Feb 1987) ISSN: 0379-0355 [Print] Spain
PMID3295429 (Publication Type: Journal Article)
Chemical References
  • Antihypertensive Agents
  • Diuretics
  • Pyridinium Compounds
  • besulpamide
  • Desoxycorticosterone
  • Captopril
Topics
  • Animals
  • Antihypertensive Agents
  • Captopril (pharmacology)
  • Desoxycorticosterone (antagonists & inhibitors)
  • Diuretics
  • Dogs
  • Drug Synergism
  • Male
  • Mice
  • Pyridinium Compounds (pharmacology)
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred Strains

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