Identification of differentially expressed long non-coding RNAs and mRNAs in orbital adipose/connective tissue of thyroid-associated ophthalmopathy.

Abstract

Extracellular matrix remodeling and orbital adipose/connective tissue expansion are two key features of thyroid-associated ophthalmopathy (TAO). Recent studies have indicated the critical role of long non-coding RNAs (lncRNAs) in the pathogenesis of ocular disorders. However, little is known about the roles of lncRNAs in orbital adipose/connective tissue of TAO. In this study, the profiles of lncRNAs and mRNAs in the orbital adipose/connective tissue of TAO were identified by RNA sequencing. A total of 809 differential lncRNAs and 607 differential mRNAs were identified, among which 52 genes were found to be significantly related to the extracellular matrix. Co-expression network analysis suggested that lncRNAs might regulate extracellular matrix remodeling in orbital adipose/connective tissue of TAO. Additionally, the target genes of lncRNAs involved in the lipid metabolism and cytokine-cytokine receptor interaction were also identified. These results may provide potential regulatory mechanisms of lncRNAs in the orbital adipose/connective tissue of TAO.

• Authors: Lianqun Wu, Lei Li, Yu Liang, Xinxin Chen, Pei Mou, Guohua Liu, Xiantao Sun, Bing Qin, Shujie Zhang, Chen Zhao
• Journal: Genomics (Genomics) Vol. 113 Issue 1 Pt 2 Pg. 440-449 (01 2021) ISSN: 1089-8646 [Electronic] United States
• PMID: 32919017 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2020. Published by Elsevier Inc.

Chemical References

• RNA, Long Noncoding
• RNA, Messenger

Topics

• Adipose Tissue (metabolism)
• Adult
• Connective Tissue (metabolism)
• Eye (metabolism)
• Female
• Gene Regulatory Networks
• Graves Ophthalmopathy (genetics, metabolism)
• Humans
• Male
• Middle Aged
• RNA, Long Noncoding (genetics, metabolism)
• RNA, Messenger (genetics, metabolism)