Abstract | OBJECTIVE: STUDY DESIGN: We retrospectively reviewed both MII-pH and endoscopy/histopathology performed in 1-year-old children with esophageal atresia who were followed up in accordance with international recommendations. Demographic data and clinical characteristics were also reviewed to investigate factors associated with abnormal GERD investigations. RESULTS: In our study cohort of 48 children with esophageal atresia, microscopic esophagitis was found in 33 (69%) and pathological esophageal acid exposure on MII-pH was detected in 12 (25%). Among baseline variables, only the presence of long-gap esophageal atresia was associated with abnormal MII-pH. Distal baseline impedance was significantly lower in patients with microscopic esophagitis, and it showed a very good diagnostic performance in predicting histological changes. CONCLUSIONS: Histological esophagitis is highly prevalent at 1 year after esophageal atresia repair, but our results do not support a definitive causative role of acid-induced GERD. Instead, they support the hypothesis that chronic stasis in the dysmotile esophagus might lead to histological changes. MII-pH may be a helpful tool in selecting patients who need closer endoscopic surveillance and/or benefit from acid suppression.
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Authors | Renato Tambucci, Sara Isoldi, Giulia Angelino, Filippo Torroni, Simona Faraci, Francesca Rea, Erminia Francesca Romeo, Tamara Caldaro, Luciano Guerra, Anna Chiara Iolanda Contini, Monica Malamisura, Giovanni Federici di Abriola, Paola Francalanci, Andrea Conforti, Luigi Dall'Oglio, Paola De Angelis |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 228
Pg. 155-163.e1
(01 2021)
ISSN: 1097-6833 [Electronic] United States |
PMID | 32918920
(Publication Type: Journal Article)
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Copyright | Copyright © 2020 Elsevier Inc. All rights reserved. |
Topics |
- Adolescent
- Child
- Electric Impedance
- Endoscopy, Gastrointestinal
- Esophageal Atresia
(surgery)
- Esophageal pH Monitoring
(methods)
- Esophagoplasty
(adverse effects)
- Esophagus
(metabolism, physiopathology)
- Female
- Follow-Up Studies
- Gastroesophageal Reflux
(diagnosis, etiology, physiopathology)
- Humans
- Male
- Manometry
- Postoperative Complications
- Retrospective Studies
- Time Factors
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