Abstract |
Efficacy and tolerance of the anticholinergic and calcium antagonistic drug terodiline (Mictrol) were investigated in comparison to placebo in 42 children with diurnal enuresis. The study was double-blind with a modified cross-over design with 2 treatment periods of 4 weeks. Terodiline in a daily dose of 25 mg was well tolerated. A statistically significant decrease in the number of wet episodes per day was found with terodiline when compared to placebo. In addition a high patient preference for terodiline was observed. This study shows that terodiline is effective in the treatment of daytime enuresis in children. The low incidence of side-effects also favours the use of terodiline in children.
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Authors | M Elmér, J P Nørgaard, J C Djurhuus, T Adolfsson |
Journal | Scandinavian journal of primary health care
(Scand J Prim Health Care)
Vol. 6
Issue 2
Pg. 119-24
(May 1988)
ISSN: 0281-3432 [Print] United States |
PMID | 3291041
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Butylamines
- Calcium Channel Blockers
- terodiline
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Topics |
- Adolescent
- Butylamines
(therapeutic use)
- Calcium Channel Blockers
(therapeutic use)
- Child
- Child, Preschool
- Clinical Trials as Topic
- Double-Blind Method
- Enuresis
(drug therapy)
- Female
- Humans
- Male
- Random Allocation
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