Fatty Liver, and Not Visceral Fat, Is More Associated with Liver Fibrosis and Diabetes in Non-Obese Japanese Individuals: A Cross-Sectional Study.

Abstract

Asians are known to be more likely than Westerners to develop fatty liver and lifestyle-related diseases in spite of their weight. However, the relationship between fat accumulation and lifestyle-related diseases in non-obese Asians is unknown. Therefore, this study aimed to analyze visceral fat and hepatic fat in participants with a normal body mass index (BMI) and examine their characteristics during a medical checkup. This cross-sectional study was conducted on 663 of 1142 patients who underwent abdominal ultrasonography and who had an alcohol intake (converted to ethanol) of <30 g/day for males and <20 g/day for females and a BMI of <25 kg/m2 during a health checkup. Participants were classified into four groups: group A, visceral fat accumulation (VFA) (-) and fatty liver (FL) (-) (n = 549); group B, VFA (+) and FL (-) (n = 32); group C, VFA (-) and FL (+) (n = 58); and group D, VFA (+) and FL (+) (n = 24). The frequencies of lifestyle-related disease complications, liver function tests, and liver fibrosis were evaluated among the four groups. Compared with group A (control), groups B, C, and D had a higher number of males, BMI, abdominal circumference, ALT, AST, γ-GTP, triglyceride, uric acid, fasting blood sugar levels, and incidence of hyperlipidemia. Groups C and D had higher ALT, HbA1c, cholinesterase, and triglyceride levels, FIB4 index, and the number of patients with diabetes mellitus (DM) than groups A and B; however, there was no difference between groups A and B. FL is a risk factor of DM and liver fibrosis in non-obese Japanese individuals; however, VFA only is not a risk factor of DM and liver fibrosis.

• Authors: Noriyo Urata, Miwa Kawanaka, Ken Nishino, Katsunori Ishii, Tomohiro Tanikawa, Mitsuhiko Suehiro, Takako Sasai, Ken Haruma, Hirofumi Kawamoto, Jun Nakamura, Noriaki Manabe, Tomoari Kamada
• Journal: Life (Basel, Switzerland) (Life (Basel)) Vol. 10 Issue 9 (Sep 04 2020) ISSN: 2075-1729 [Print] Switzerland
• PMID: 32899741 (Publication Type: Journal Article)