CDK4/6 Inhibitors in Hormone Receptor-Positive Metastatic Breast Cancer: Current Practice and Knowledge.

Abstract

Treatment paradigms in advanced hormone receptor (HR)-positive breast cancer were substantially transformed with cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) approval. The addition of these drugs to endocrine treatment profoundly improved progression-free and overall survival. Additionally, other important endpoints, such as the response rate, time to chemotherapy, and a delay in quality of life deterioration, were positively impacted by CDK4/6 inhibitors' addition to the treatment of advanced HR-positive breast cancer. This review article will summarize current knowledge on CDK4/6 inhibitors in clinical practice for advanced HR-positive metastatic breast cancer, as well as describe recent efforts to more precisely characterize mechanisms of sensitivity and resistance to these drugs, both on the molecular and clinical characterization level.

• Authors: Debora de Melo Gagliato, Antonio C Buzaid, Jose Manuel Perez-Garcia, Antonio Llombart, Javier Cortes
• Journal: Cancers (Cancers (Basel)) Vol. 12 Issue 9 (Sep 01 2020) ISSN: 2072-6694 [Print] Switzerland
• PMID: 32882980 (Publication Type: Journal Article, Review)