[Combined use of mytilan and gentamycin in experimental infections ].

Abstract

It was shown that mytilan, a polysaccharide isolated from the mantle of Crenomytilus grayanus stimulated the host nonspecific resistance to infections. This was evident from the survival rate of the animals infected with lethal doses of E. coli and S. aureus. In addition, the combined use of gentamicin and mytilan in treatment of the infections caused by the above organisms enabled to increase the antibiotic therapy efficacy with using lower doses of both the antibiotic and the polysaccharide.

• Authors: N V Krylova, A N Lobuseva, N N Besednova
• Journal: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] (Antibiot Khimioter) Vol. 33 Issue 1 Pg. 61-3 (Jan 1988) ISSN: 0235-2990 [Print] Russia (Federation)
• Vernacular Title: Kombinirovannoe primenenie mitilana i gentamitsina pri nekotorykh éksperimental'nykh infektsiiakh.
• PMID: 3288147 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Gentamicins
• Polysaccharides
• mytilan

Topics

• Animals
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Drug Therapy, Combination
• Escherichia coli Infections (drug therapy, immunology, mortality)
• Gentamicins (therapeutic use)
• Immunity, Innate (drug effects)
• Mice
• Polysaccharides (therapeutic use)
• Staphylococcal Infections (drug therapy, immunology, mortality)