Cellular senescence and cancer: Focusing on traditional Chinese medicine and natural products.

Abstract

Cancer is the principal cause of death and a dominant public health problem which seriously threatening human life. Among various ways to treat cancer, traditional Chinese medicine (TCM) and natural products have outstanding anti-cancer effects with their unique advantages of high efficiency and minimal side effects. Cell senescence is a physiological process of cell growth stagnation triggered by stress, which is an important line of defence against tumour development. In recent years, active ingredients of TCM and natural products, as an interesting research hotspot, can induce cell senescence to suppress the occurrence and development of tumours, by inhibiting telomerase activity, triggering DNA damage, inducing SASP, and activating or inactivating oncogenes. In this paper, the recent research progress on the main compounds derived from TCM and natural products that play anti-cancer roles by inducing cell senescence is systematically reviewed, aiming to provide a reference for the clinical treatment of pro-senescent cancer.

• Authors: Yiman Liu, Shenshen Yang, Kailong Wang, Jia Lu, Xiaomei Bao, Rui Wang, Yuling Qiu, Tao Wang, Haiyang Yu
• Journal: Cell proliferation (Cell Prolif) Vol. 53 Issue 10 Pg. e12894 (Oct 2020) ISSN: 1365-2184 [Electronic] England
• PMID: 32881115 (Publication Type: Journal Article, Review)
• Copyright: © 2020 The Authors. Cell Proliferation published by John Wiley & Sons Ltd.

Chemical References

• Alkaloids
• Biological Products
• Flavonoids
• Phenols
• Reactive Oxygen Species

Topics

• Alkaloids (chemistry, pharmacology, therapeutic use)
• Biological Products (chemistry, pharmacology, therapeutic use)
• Cellular Senescence (drug effects)
• DNA Damage (drug effects)
• Flavonoids (chemistry, pharmacology, therapeutic use)
• Humans
• Medicine, Chinese Traditional
• Neoplasms (drug therapy, pathology)
• Phenols (chemistry, pharmacology, therapeutic use)
• Reactive Oxygen Species (metabolism)