Additional pharmacological activity of I-modulia and generation of two newly designed extracts of Aquaphilus dolomiae culture for dermocosmetic actives.

Abstract

Aquaphilus dolomiae (AD) is a unique isolate from Avène Thermal Spring Water. I-Modulia, the first biotech extract from culture of AD, was used as immune modulator in Th2 inflammatory models. In this short publication, firstly we describe generation of two AD de novo extracts specifically designed for repairing and for neuroinflammation modulation activities which will be described, respectively, in two other articles in this supplement. Finally, for I-modulia, we describe new data on inhibition of human mast cell degranulation in vitro and its effect on substance P-induced neurogenic inflammation on ex vivo human skin explants.

• Authors: T Nguyen, B Chol, M Maitre, K Ravard-Helffer, F Farinole, F Lestienne, N Castex-Rizzi
• Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 34 Suppl 5 Pg. 27-29 (Aug 2020) ISSN: 1468-3083 [Electronic] England
• PMID: 32870555 (Publication Type: Journal Article)
• Copyright: © 2020 European Academy of Dermatology and Venereology.

Chemical References

• Cosmetics

Topics

• Cosmetics
• Humans
• Mast Cells (drug effects)
• Neisseriaceae
• Skin